A sandwich is a whole meal in itself, making it difficult to perfect. Here’s a list of the best ones.
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MDMA, better known as ecstasy, was the demonized dance drug of club culture, the chemical generation’s stimulant of choice from the late Eighties to early Noughties. But as its cultural influence wanes, could E be set for a second life as a treatment for sufferers of post-traumatic stress disorder? As clinical trials on the drug begin in the UK, Esquire gets on one—under laboratory conditions, of course.
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Liked the print cover? Here’s the alternate cover that Esquire tablet and smartphone readers get to see.     Haven’t got a copy yet? Grab one at http://bit.ly/VInG9a  

Gary Andrew Poole on Manny Pacquiao’s stunning loss to Juan Manuel Marquez. An Esquire Exclusive.
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